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Therapeutic Areas

Deployed in 20+ 
Therapeutic Areas

Unfiltered raw data allows us to develop new algorithms and objective health measures for assessing outcomes in any therapeutic area. Continuous measurement of patients 24/7 gives us the true understanding of lifestyles and behaviours.

We are disease agnostic, with our devices and data analytics being successfully used across a wide range of therapeutic areas and conditions. Currently, we are participating in trials that impact in many areas from cardiology to dermatology. Our technologies are rapidly emerging as the gold standard in digital endpoint and biomarker development.

Our technology has been utilized in the following areas:

Dermatology
Endocrinology
Orthopaedics
Immunology
Ophthalmology
Behaviour Change
Psychiatry
Paediatrics
Respiratory
Renal & Gastroenterology
Women's Health
Healthy Ageing
Occupational Health
Cardiology
Metabolism
Musculoskeletal
Oncology
Infectious Diseases
Sleep Medicine

Neurology

The physical manifestation of many neurological conditions can be measured objectively with continuous, high resolution accelerometry assessment. Tremor and other involuntary movements have characteristic signals that can be identified and quantified. Changes in gait, posture and rest-activity rhythms also provide vital data to support ongoing disease monitoring and management.

Key Indications 

Parkinson's Disease
Epilepsy
Stroke
Concussion
Motor Activity
Huntington's Disease
Multiple Sclerosis
Dementia
ADHD
Austism
Tourette's Syndrome

Wrist-worn Accelerometer Measures of Movement by People with Parkinson’s Attending Dance Classes

This study used GENEActiv devices to measure the level of physical activity of people with Parkinson's during a dance class. Data across the time bins showed the accelerometers accurately tracked movements.
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Physical Activity in Non-Disabled People with Early Multiple Sclerosis

The aims of this study were to objectively quantify PA levels in non-disabled PwMS, to compare the time spent daily at different PA levels with healthy subjects, and to examine the association of PA with disability, and clinical measures in PwMS.
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Psychiatry

Key Indications 

Psychology
Cognitive Health
Mental Health
Bipolar Disorder
Cognitive Function
Anorexia
Schizophrenia
Eating Disorder

Patterns of Activity Correlate with Symptom Severity in Major Depressive Disorder Patients

The aim of this study was to investigate whether features of activity patterns correlate with severity of depression symptoms.
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Sleep Disturbances in the Context of Neurohormonal Dysregulation in Patients with Bipolar Disorder

This study investigated the possible link between subjective and objective sleep disturbances in inter-episode BD, changes in melatonin and cortisol levels, and circadian melatonin alignment.
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Cardiology

Understanding patterns of physical behaviour in chronic heart disease, heart failure and circulatory diseases provides deep insight into disease progression, cardiovascular performance and recovery after interventions. These measurements require long term wear or frequent, repeat assessments in real world settings. The low patient burden of Activinsights’ wearables has been proven in many studies with high adherence rates.

Key Indications 

Circulatory Diseases
Heart Disease
Heart Failure
Vasculitis
Cardiovascular Disease

Rationale and Design of the SafeHeart Study

This study looked at the development and testing of a mHealth tool for the prediction of arrhythmic events and implantable cardioverter-defibrillator therapy.
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Activinsights and Cardialysis Announce a New Strategic Partnership


Activinsights is excited to announce a new partnership agreement with Cardialysis, a leading Cardiovascular Research Organisation with an exclusive focus on cardiology.
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Dermatology

The ability of our unfiltered raw data accelerometry to detect and quantify fine motor movements has placed Activinsights’ technologies at the forefront of scratch detection in dermatology. The objective measurement of nocturnal scratch in combination with sleep and daily living data will revolutionise the development of treatments for atopic dermatitis and psoriasis.

Key Indications 

Atopic Dermatitis
Sarcoidosis

Detection of Nocturnal Scratching Movements in Patients with Atopic Dermatitis Using Accelerometers

High-resolution wrist actigraphy is a non-invasive method to record movement. This paper presents an algorithm to detect nocturnal scratching events based on
actigraphy data.
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Development of Digital Measures for Nighttime Scratch and Sleep using Wrist-worn Wearable Devices

Patients with atopic dermatitis experience increased nocturnal pruritus which leads to scratching and sleep disturbances. Objective measurements of nighttime scratching and sleep quantity can help assess the efficacy of an intervention.
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Paediatrics

Key Indications 

Growth
Development
Behaviour

Sleep Behaviour of Infants with Infantile Hemangioma Treated with Propranolol—a Cohort Study

This cohort study consisted of a prospective cohort of infants with propranolol treatment for IH, whose sleep behavior was assessed over time, and a comparison with an identically designed, historical cohort of untreated infants, whose sleep behavior was assessed in the same manner without any temporal matching.
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Physical Activity Predicts Task-related Behaviour, Affect and Tiredness in the Primary School Classroom

This study investigated the dose–response relationship between acute physical activity (PA) intensity during physical education (PE) lessons (dose), and task behaviour and learning experiences in the classroom after PE (response), and mediation effects of acute PA on-task behaviour via learning experiences.
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Metabolism

Key Indications 

Obesity
Metabolic Syndrome
Hypoglycaemia
Mitochondrial Diseases
Metabolic Disorders

Impact of Time in Motion on Blood Pressure Regulation Among Patients with Metabolic Syndrome

This review assessed recent evidence on the association between objectively measured physical activity from wearable accelerometers and blood pressure (BP) in participants with metabolic syndrome (MetS).
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Timing of Objectively-Collected Physical Activity in Relation to Body Weight and Metabolic Health in Sedentary Older People

This study assessed the association between accelerometery-based daily timing of physical activity and measures of metabolic health in sedentary older people.
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Endocrinology

Key Indications 

Diabetes
Growth Hormone Deficiency
Hyperthyroidism
Gestational Diabetes

Supplemental Light Exposure Improves Sleep Architecture in People with Type 2 Diabetes

People with type 2 diabetes (T2D) suffer from sleep disorders, with the mechanism not clearly understood. This study determines whether supplemental light exposure ameliorates sleep quality and daytime sleepiness in T2D.
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Relative Protein Intake and Associations with Markers of Physical Function in those with Type 2 Diabetes

This study examined the independent associations between relative protein intake (g kg−1 day 1) and markers of physical function in those with type 2 diabetes, while also comparing with current guidelines for protein intake.
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Respiratory

Key Indications 

Asthma
Chronic Obstructive Pulmonary Disease (COPD)
Sarcoidosis
Cystic Fibrosis
Pulmonary Fibrosis
Respiratory Diseases
Lung Disease

High Intensity Interval Training Versus Moderate Intensity Continuous Training for People with Interstitial Lung Disease

This trial compared the clinical benefits of high intensity interval exercise training versus the standard pulmonary rehabilitation method of continuous training at moderate intensity in people with fibrotic interstitial lung disease.
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Calibration and Cross-validation of Accelerometry in Children and Adolescents with Cystic Fibrosis

Thirty-five children and adolescents with Cystic Fibrosis, had their energy expenditure and triaxial acceleration measured during six daily activities of varying intensities.
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Musculoskeletal

Key Indications 

Osteoporosis
Achondroplasia
Bone Health
Musculoskeletal Diseases
Muscular Dystrophy
Myotonic Dystrophy
Sarcopenia
Myopathy
Osteoarthritis
Carpal Tunnel Syndrome

Assessment of Physical Activity and Muscle Function in Adult Inflammatory Myopathies

The aim of this study was to summarize the outcome measures used in the assessment and monitoring of muscle function and physical activity in the management idiopathic inflammatory myopathy.
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Active Video Games Improve Muscular Fitness and Motor Skills in Children with Overweight or Obesity

The aim of this study was to examine the influence of an active video games (AVG) intervention combined with multicomponent exercise on muscular fitness, physical activity (PA), and motor skills in children with overweight or obesity.
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Orthopaedics

Key Indications 

Fracture Recovery
Knee Replacement
Hip Replacement

Quantifying Shoulder Activity after Rotator Cuff Repair: Technique and Preliminary Results

The objectives of this study were to assess the precision, accuracy, and feasibility of a wrist-worn triaxial accelerometer for measuring shoulder activity.
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Mental Toughness as a Moderator of the Intention–Behaviour Gap in the Rehabilitation of Knee Pain

The purpose of this study was to investigate the role of mental toughness in maximising the effect of intentions to perform rehabilitative exercises on behaviour among a sample of people with knee pain.
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Renal & Gastroenterology

Key Indications 

Non-Alcoholic Fatty Liver Disease (NAFLD)
Non-alcoholic Steatohepatitis (NASH)
Inguinal Hernia
Kidney Transplant
Renal/Hepatic Impairment
Kidney Disease
Liver Disease

Fasting before Living-Kidney Donation: Effect on Donor Well-Being and Postoperative Recovery

This study used GENEActiv to determine whether 2.5 days of fasting reduces postoperative fatigue score in subjects undergoing living-kidney donation.
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Objectively Measured Physical Activity Is Inversely Associated With Nonalcoholic Fatty Liver Disease

In this study, researchers investigated the association between objectively measured physical activity and the impact of metabolic health in these associations.
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Oncology

Key Indications 

Colorectal Cancer
Breast Cancer
Pancreatic Cancer
Childhood Cancers

Improving Physical Activity Levels Among Childhood Cancer Survivors

This study explores survivors’ perceptions oftheir PA and fitness levels, and their objective PA levels using accelerometry. They then tested the feasibility of a digital educational intervention.
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Quality of Life of Locally Advanced Pancreatic Cancer Patients After FOLFIRINOX Treatment

In this study, researchers investigated quality of life, pain, sleep, and activity levels in locally advanced pancreatic cancer patients after FOLFIRINOX treatment.
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Immunology

Key Indications 

Rheumatoid Arthritis
Allergies
Inflammatory Disease

Free-Living Motor Activity Monitoring in Ataxia-Telangiectasia

In this study, researchers test the hypothesis that metrics derived from the GENEActiv worn at home provide accurate, reliable, and interpretable information about neurological disease severity in children with A-T.
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Measuring Activity in Patients with Sarcoidosis - A Pilot Trial of Two Wrist-Worn Accelerometer Devices

In this study patients with sarcoidosis wore two wrist-worn activity monitors (GENEActiv and Actigraph GT3X-bt) separately for seven days each and a clear preference was demonstrated for the GENEActiv.
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Women’s Health

Key Indications 

Contraception
Endometriosis
Hot Flushes
Sexual Dysfunction
Menstrual Cycle
Pregnancy

Absolute Accelerometer-Based Intensity Prescription Compared to Physiological Variables in Pregnant and Nonpregnant Women

Estimation of the intensity of physical activity based on absolute accelerometer cut points (Cp) likely over- or underestimates intensity for a specific individual. The purpose of this study was to investigate the relationship between absolute moderate intensity Cp and the first ventilatory threshold.
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How Many Days are Needed to Estimate Wristworn Accelerometry-Assessed Physical Activity During the Second Trimester in Pregnancy?

This study assessed the optimal number of days needed to obtain reliable estimates of overall PA and moderate-to-vigorous physical activity during the 2nd trimester in pregnancy using a GENEActiv.
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Infectious Diseases

Key Indications 

COVID-19
Hepatitis B & C
HIV
Influenza

Relationship Between Parents' and Children's Objectively Assessed Movement Behaviours Prior to and During the COVID-19 Pandemic

The aim of this study was to compare levels of physical activity, sedentary behaviour, and sleep time in children prior to and during the pandemic.
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An Investigation of Daily Experiences of Stress, Physical Activity, and Sleep During the COVID-19 Pandemic

The purposes of this study was to explore time-varying associations of MVPA and sleep with momentary perceived stress in adults forced to work from home during COVID-19.
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Ophthalmology

Key Indications 

Macular Degeneration
Vision Impairment

Impact of Visual Impairment on Physical
Activity in Early and Late Age-Related Macular Degeneration

This study used GENEActiv to assess the impact of visual impairment under both high and low luminance conditions on levels of PA in early and late AMD.
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Impaired Vision and Physical Activity in Childhood and Adolescence: Findings from the Millennium Cohort Study

This study investigated if impaired vision is associated with reduced levels and differences in types of physical activity to identify barriers or enablers to achieving healthy PA levels.
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Healthy Ageing

Key Indications 

Frailty
Palliative Care
Multimorbidity
Lifestyle

Accelerometer-Determined Physical Behavior Metrics and their Associations with Sarcopenia among Oldest-Old Adults

This study determined that oldest-old adults with higher total volumes of moderate to vigorous physical activity showed a lower likelihood for a probable sarcopenic condition in the primary sample.
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Real-world Gait Speed Estimation, Frailty and Handgrip Strength: A Cohort-Based Study

This study provides evidence that real-world gait speed can be estimated using a wrist-worn wearable system, and can be used as reliable indicator of age-related functional decline.
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Sleep Medicine

Key Indications 

Chronic Insomnia
Excessive Daytime Sleepiness (EDS)
Narcolepsy
Obstructive Sleep Apnoea (OSA)
Jet Lag
Polysomnography (PSG)
Restless Legs Syndrome (RLS)
Periodic Limb Movement Disorder (PLM)
Shift Worker Syndrome

Intelligence Predicts Better Cognitive Performance After Normal Sleep but Larger Vulnerability to Sleep Deprivation

This study looked at whether those with higher intelligence are also more resilient to the cognitive effects of insufficient sleep.
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Comparing GENEActiv against Actiwatch-2 over Seven Nights Using a Common Sleep Scoring Algorithm and Device-Specific Wake Thresholds

This study compared the reliability of GENEActiv against Actiwatch-2 and found the overall reliability to be higher.
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Behaviour Change

Key Indications 

Health Promotion
Lifestyle Intervention
Education

Promoting Physical Activity with Self-Management Support for Those with Multimorbidity

This study used GENEActiv to investigate the impact of a structured, theoretically driven, self-management group education programme on habitual PA levels in people with multimorbidity.
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Digital Behavior Change Interventions to Promote Physical Activity and/or Reduce Sedentary Behavior in Older Adults

This study used GENEActiv to determine whether Digital Behaviour Change Interventions may increase physical activity and physical functioning, and reduce sedentary time and systolic blood pressure in older adults.
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Occupational Health

Key Indications 

Stress
Fatigue
Shift Patterns

Evaluation of Environmental, Social, and Behavioral Modulations of the Circadian Phase of Dancers Trained in Shifts

This study concluded that the Circadian phase was earlier in morning than in night dancers in real-life conditions and sleep time (and night-shift chronotypes) correlated with the circadian phase.
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The Effect of Time on Task, Sleep Deprivation, and Time of Day on Simulated Driving Performance

This study investigated the combined effect of sleep deprivation, time of day, and time on task as a workload factor on driving performance.
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Data Acquisition & Analysis

We offer a full-scale service for clinical trials and academic research projects, including study design, global deployment, training, data analysis and more.
Find out more

Remote Monitoring Experts

Activinsights is a digital health company that specialises in the objective measurement of physical behaviours and lifestyle within the clinical trials, health management and research markets.
About Us
How can we help you?
Our friendly team have extensive experience in remote monitoring technology and can advise you on what products and services will best suit your project needs.

Contact us to discuss your requirements.
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